95: Autologous hematopoietic cell transplantation (auto-HCT) in chronic lymphocytic leukemia (CLL)

Hematopoietic stem cell transplantation for chronic lymphocytic leukemia.

Conventional therapies for chronic lymphocytic leukemia are not likely to provide a cure, prompting the use of more aggressive approaches. High-dose therapy with autologous and allogeneic bone marrow or blood stem cell transplantation appear to induce a prolonged period of disease-free survival in selected patients with this indolent disease. Significant questions were raised, however, in terms...

CHRONIC LYMPHOCYTIC LEUKEMIA Treatment algorithms in CLL

CLL therapy has changed dramatically over the last few years. This development has been aided by progress in 2 areas: (1) a better understanding of CLL biology (and with it discovery and characterization of new prognostic markers); and (2) emergence of novel agents. The combined impact of advances in these areas is leading to new concepts and approaches in CLL therapy. Treatment of CLL has been...

Stem cell transplantation in chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) remains incurable with standard therapy. Most patients with CLL have an indolent clinical course, but it is possible to identify patients with high-risk disease. Younger patients with adverse risk factors will die from their disease, and are therefore candidates for clinical trials exploring hematopoietic stem cell transplantation (HSCT). Autologous SCT is fea...

Stem Cell Transplantation in Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia (CLL) — Staging and Prognosis

Chronic lymphocytic leukemia (CLL) affects the B-cells of the immune system and is, as the most common leukemia in adults, an important hematological differential diagnosis. It often hardly progresses for years and therefore a CLL does not always need immediate therapy. In the past years especially, a lot has happened with regard to diagnostic options and treatment, so that being informed about...